Overview
ISO/TR 13014:2012/Cor 1:2012 is a technical corrigendum to the original ISO Technical Report 13014:2012, which provides guidance on the physico-chemical characterization of engineered nanoscale materials for toxicologic assessment. Developed by ISO Technical Committee ISO/TC 229 on Nanotechnologies, this corrigendum addresses specific editorial corrections to enhance clarity and accuracy in the document.
This update is crucial for professionals involved in nanotechnology research, regulatory compliance, and toxicology because it ensures precise terminology and measurement practices when assessing the potential health risks of nanoscale materials. The corrigendum primarily emphasizes the correct use of the term "dispersibility" in place of the previously incorrect term "dispensability," which is vital for standardized communication and assessment methodologies.
Key Topics
- Physico-chemical characterization: Essential properties of engineered nanomaterials such as size, shape, surface area, surface chemistry, and dispersibility that influence their behavior and toxicity.
- Dispersibility correction: Clarification and correction of terminology from "dispensability" to "dispersibility" to accurately describe the ability of nanoparticles to be uniformly distributed in a medium, which affects toxicological outcomes.
- Measurement methods: Guidance on techniques to evaluate dispersibility alongside other characterization parameters to ensure reliable toxicologic assessments.
- Nanomaterial safety assessment: Framework for integrating physico-chemical data into toxicology protocols to evaluate the potential health risks safely and effectively.
Applications
ISO/TR 13014:2012/Cor 1:2012 serves as an essential reference for:
- Nanotechnology researchers and laboratories conducting characterization and safety testing of nanomaterials to ensure consistency in terminology and methodology.
- Regulatory bodies and standardization organizations aiming to harmonize nanomaterial safety assessment frameworks globally by adopting standardized definitions and measurement criteria.
- Industries producing engineered nanoscale materials, including pharmaceuticals, cosmetics, electronics, and materials science, to apply correct physico-chemical characterization in product development and risk management.
- Toxicologists and health professionals evaluating exposure risks and toxic effects of nanomaterials based on accurate physico-chemical properties, particularly dispersibility, which influences bioavailability.
Related Standards
- ISO/TS 12901 series - Nanotechnologies - Occupational risk management applied to engineered nanomaterials.
- ISO/TR 13121 - Nanotechnologies - Nanomaterial risk evaluation.
- ISO 80004 series - Vocabulary for Nanotechnology.
- OECD Guidelines for the Testing of Manufactured Nanomaterials - Providing complementary testing methods for nanomaterial safety.
By incorporating this technical corrigendum, organizations and experts can ensure more accurate, reliable, and standardized nanomaterial characterization essential for safe applications and regulatory compliance. Using ISO/TR 13014:2012/Cor 1:2012 supports the development of safer nanotechnologies through improved toxicologic assessment protocols.
Open preview (PDF)Nanotechnologies — Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment — Technical Corrigendum 1
